Cargando…

MSX2 safeguards syncytiotrophoblast fate of human trophoblast stem cells

Multiple placental pathologies are associated with failures in trophoblast differentiation, yet the underlying transcriptional regulation is poorly understood. Here, we discovered msh homeobox 2 (MSX2) as a key transcriptional regulator of trophoblast identity using the human trophoblast stem cell m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hornbachner, Ruth, Lackner, Andreas, Papuchova, Henrieta, Haider, Sandra, Knöfler, Martin, Mechtler, Karl, Latos, Paulina A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2021
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449346/ https://www.ncbi.nlm.nih.gov/pubmed/34507999 http://dx.doi.org/10.1073/pnas.2105130118

Ejemplares similares

The Fgf/Erf/NCoR1/2 repressive axis controls trophoblast cell fate
por: Lackner, Andreas, et al.
Publicado: (2023)

Transcription factor networks in trophoblast development
por: Papuchova, Henrieta, et al.
Publicado: (2022)

Transforming growth factor-β signaling governs the differentiation program of extravillous trophoblasts in the developing human placenta
por: Haider, Sandra, et al.
Publicado: (2022)

Placenta-derived macaque trophoblast stem cells: differentiation to syncytiotrophoblasts and extravillous trophoblasts reveals phenotypic reprogramming
por: Schmidt, Jenna Kropp, et al.
Publicado: (2020)

MSX2 Induces Trophoblast Invasion in Human Placenta
por: Liang, Hao, et al.
Publicado: (2016)

MSX2 in ameloblast cell fate and activity
por: Babajko, Sylvie, et al.
Publicado: (2015)

Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta
por: Meinhardt, Gudrun, et al.
Publicado: (2020)

Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta
por: Haider, Sandra, et al.
Publicado: (2018)

WNT and NOTCH signaling in human trophoblast development and differentiation
por: Dietrich, Bianca, et al.
Publicado: (2022)

Reactive oxygen species from mitochondria impacts trophoblast fusion and the production of endocrine hormones by syncytiotrophoblasts
por: Walker, O’Llenecia S., et al.
Publicado: (2020)

Efficient Induction of Syncytiotrophoblast Layer II Cells from Trophoblast Stem Cells by Canonical Wnt Signaling Activation
por: Zhu, Dongmei, et al.
Publicado: (2017)

Inefficient development of syncytiotrophoblasts in the Atp11a-deficient mouse placenta
por: Ochiai, Yuki, et al.
Publicado: (2022)

Omics Approaches to Study Formation and Function of Human Placental Syncytiotrophoblast
por: Jaremek, Adam, et al.
Publicado: (2021)

BMI1 fine-tunes gene repression and activation to safeguard undifferentiated spermatogonia fate
por: Liu, Ruiqi, et al.
Publicado: (2023)

Caspase-mediated apoptosis of trophoblasts in term human placental villi is restricted to cytotrophoblasts and absent from the multinucleated syncytiotrophoblast
por: Longtine, Mark S, et al.
Publicado: (2012)

Regulation of endogenous retrovirus–derived regulatory elements by GATA2/3 and MSX2 in human trophoblast stem cells
por: Du, Cui, et al.
Publicado: (2023)

Expression and regulation of the Msx1 natural antisense transcript during development
por: Coudert, Amélie E., et al.
Publicado: (2005)

Polo-like kinase acts as a molecular timer that safeguards the asymmetric fate of spindle microtubule-organizing centers
por: Matellán, Laura, et al.
Publicado: (2020)

Human placenta and trophoblast development: key molecular mechanisms and model systems
por: Knöfler, Martin, et al.
Publicado: (2019)

Enhanced HIF2α expression during human trophoblast differentiation into syncytiotrophoblast suppresses transcription of placental growth factor
por: Fujii, Tatsuya, et al.
Publicado: (2017)

The Immunomodulatory Role of Syncytiotrophoblast Microvesicles
por: Southcombe, Jennifer, et al.
Publicado: (2011)

The role of interleukin-1β in human trophoblast motility
por: Prutsch, N., et al.
Publicado: (2012)

RNA-Seq identifies genes whose proteins are transformative in the differentiation of cytotrophoblast to syncytiotrophoblast, in human primary villous and BeWo trophoblasts
por: Azar, Christopher, et al.
Publicado: (2018)

Functional interactions between Dlx2 and lymphoid enhancer factor regulate Msx2
por: Diamond, Evan, et al.
Publicado: (2006)

Hippo signaling cofactor, WWTR1, at the crossroads of human trophoblast progenitor self-renewal and differentiation
por: Ray, Soma, et al.
Publicado: (2022)

Mga safeguards embryonic stem cells from acquiring extraembryonic endoderm fates
por: Qin, Jinzhong, et al.
Publicado: (2021)

Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells
por: Latos, Paulina A., et al.
Publicado: (2015)

Msx1 and Msx2 function together in the regulation of primordial germ cell migration in the mouse
por: Sun, Jingjing, et al.
Publicado: (2016)

IFPA Award in Placentology Lecture: Molecular regulation of human trophoblast invasion
por: Knöfler, M., et al.
Publicado: (2012)

ADP-ribosyltransferases Parp1 and Parp7 safeguard pluripotency of ES cells
por: Roper, Stephen J., et al.
Publicado: (2014)

Human placental trophoblast invasion and differentiation: a particular focus on Wnt signaling
por: Knöfler, Martin, et al.
Publicado: (2013)

Immunologic activation of human syncytiotrophoblast by Plasmodium falciparum
por: Lucchi, Naomi W, et al.
Publicado: (2008)

Evidence for Transcriptional Activity in the Syncytiotrophoblast of the Human Placenta
por: Ellery, P.M., et al.
Publicado: (2009)

Studies of the dynamics of nuclear clustering in human syncytiotrophoblast
por: Calvert, S J, et al.
Publicado: (2016)

Syncytiotrophoblast-Derived Extracellular Vesicles in Pathophysiology of Preeclampsia
por: Han, Cha, et al.
Publicado: (2019)

CRIPTO-1 Is Immunolocalized in the Syncytiotrophoblast of Ampullary Pregnancies
por: Cabar, Fábio Roberto, et al.
Publicado: (2022)

Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium
por: Chen, Yi-Hui, et al.
Publicado: (2008)

The Dual Role of HLA-C in Tolerance and Immunity at the Maternal-Fetal Interface
por: Papúchová, Henrieta, et al.
Publicado: (2019)

A proteostasis network safeguards the chloroplast proteome
por: Llamas, Ernesto, et al.
Publicado: (2022)

Function and control of human invasive trophoblast subtypes: Intrinsic vs. maternal control
por: Velicky, Philipp, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_aigfheu9ht9olfkhs4ifoocan3