Cancer-associated mutations in the p85α N-terminal SH2 domain activate a spectrum of receptor tyrosine kinases

The phosphoinositide 3-kinase regulatory subunit p85α is a key regulator of kinase signaling and is frequently mutated in cancers. In the present study, we showed that in addition to weakening the inhibitory interaction between p85α and p110α, a group of driver mutations in the p85α N-terminal SH2 d...

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Detalles Bibliográficos
Autores principales: Li, Xinran, Lau, Amy Y. T., Ng, Angel S. N., Aldehaiman, Abdullah, Zhou, Yuan, Ng, Patrick K. S., Arold, Stefan T., Cheung, Lydia W. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449365/
https://www.ncbi.nlm.nih.gov/pubmed/34507989
http://dx.doi.org/10.1073/pnas.2101751118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449365/
https://www.ncbi.nlm.nih.gov/pubmed/34507989
http://dx.doi.org/10.1073/pnas.2101751118

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