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Diphthamide promotes TOR signaling by increasing the translation of proteins in the TORC1 pathway

Diphthamide, a modification found only on translation elongation factor 2 (EF2), was proposed to suppress −1 frameshifting in translation. Although diphthamide is conserved among all eukaryotes, exactly what proteins are affected by diphthamide deletion is not clear in cells. Through genome-wide pro...

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Detalles Bibliográficos
Autores principales: Zhang, Yugang, Lin, Zhewang, Zhu, Julia, Wang, Miao, Lin, Hening
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449394/
https://www.ncbi.nlm.nih.gov/pubmed/34507998
http://dx.doi.org/10.1073/pnas.2104577118