Rational design of ASCT2 inhibitors using an integrated experimental-computational approach

ASCT2 (SLC1A5) is a sodium-dependent neutral amino acid transporter that controls amino acid homeostasis in peripheral tissues. In cancer, ASCT2 is up-regulated where it modulates intracellular glutamine levels, fueling cell proliferation. Nutrient deprivation via ASCT2 inhibition provides a potenti...

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Detalles Bibliográficos
Autores principales: Garibsingh, Rachel-Ann A., Ndaru, Elias, Garaeva, Alisa A., Shi, Yueyue, Zielewicz, Laura, Zakrepine, Paul, Bonomi, Massimiliano, Slotboom, Dirk J., Paulino, Cristina, Grewer, Christof, Schlessinger, Avner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449414/
https://www.ncbi.nlm.nih.gov/pubmed/34507995
http://dx.doi.org/10.1073/pnas.2104093118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449414/
https://www.ncbi.nlm.nih.gov/pubmed/34507995
http://dx.doi.org/10.1073/pnas.2104093118

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