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Rational design of ASCT2 inhibitors using an integrated experimental-computational approach

ASCT2 (SLC1A5) is a sodium-dependent neutral amino acid transporter that controls amino acid homeostasis in peripheral tissues. In cancer, ASCT2 is up-regulated where it modulates intracellular glutamine levels, fueling cell proliferation. Nutrient deprivation via ASCT2 inhibition provides a potenti...

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Detalles Bibliográficos
Autores principales:	Garibsingh, Rachel-Ann A., Ndaru, Elias, Garaeva, Alisa A., Shi, Yueyue, Zielewicz, Laura, Zakrepine, Paul, Bonomi, Massimiliano, Slotboom, Dirk J., Paulino, Cristina, Grewer, Christof, Schlessinger, Avner
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2021
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449414/ https://www.ncbi.nlm.nih.gov/pubmed/34507995 http://dx.doi.org/10.1073/pnas.2104093118

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