KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases

BACKGROUND: Protein kinases are among the largest druggable family of signaling proteins, involved in various human diseases, including cancers and neurodegenerative disorders. Despite their clinical relevance, nearly 30% of the 545 human protein kinases remain highly understudied. Comparative genom...

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Detalles Bibliográficos
Autores principales: Huang, Liang-Chin, Taujale, Rahil, Gravel, Nathan, Venkat, Aarya, Yeung, Wayland, Byrne, Dominic P., Eyers, Patrick A., Kannan, Natarajan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449880/
https://www.ncbi.nlm.nih.gov/pubmed/34537014
http://dx.doi.org/10.1186/s12859-021-04358-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449880/
https://www.ncbi.nlm.nih.gov/pubmed/34537014
http://dx.doi.org/10.1186/s12859-021-04358-3

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