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KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases
BACKGROUND: Protein kinases are among the largest druggable family of signaling proteins, involved in various human diseases, including cancers and neurodegenerative disorders. Despite their clinical relevance, nearly 30% of the 545 human protein kinases remain highly understudied. Comparative genom...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449880/ https://www.ncbi.nlm.nih.gov/pubmed/34537014 http://dx.doi.org/10.1186/s12859-021-04358-3 |