Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

Artemis (SNM1C/DCLRE1C) is an endonuclease that plays a key role in development of B- and T-lymphocytes and in dsDNA break repair by non-homologous end-joining (NHEJ). Artemis is phosphorylated by DNA-PKcs and acts to open DNA hairpin intermediates generated during V(D)J and class-switch recombinati...

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Detalles Bibliográficos
Autores principales: Yosaatmadja, Yuliana, Baddock, Hannah T, Newman, Joseph A, Bielinski, Marcin, Gavard, Angeline E, Mukhopadhyay, Shubhashish M M, Dannerfjord, Adam A, Schofield, Christopher J, McHugh, Peter J, Gileadi, Opher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450076/
https://www.ncbi.nlm.nih.gov/pubmed/34387696
http://dx.doi.org/10.1093/nar/gkab693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450076/
https://www.ncbi.nlm.nih.gov/pubmed/34387696
http://dx.doi.org/10.1093/nar/gkab693

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