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A transferrable and integrative type I-F Cascade for heterologous genome editing and transcription modulation
The Class 1 type I CRISPR–Cas systems represent the most abundant and diverse CRISPR systems in nature. However, their applications for generic genome editing have been hindered due to difficulties of introducing the class-specific, multi-component effectors (Cascade) in heterologous hosts for funct...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450077/ https://www.ncbi.nlm.nih.gov/pubmed/34157103 http://dx.doi.org/10.1093/nar/gkab521 |