Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction

The use of a small molecule compound to reduce toxic repeat RNA transcripts or their translated aberrant proteins to target repeat-expanded RNA/DNA with a G4C2 motif is a promising strategy to treat C9orf72-linked disorders. In this study, the crystal structures of DNA and RNA–DNA hybrid duplexes wi...

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Detalles Bibliográficos
Autores principales: Jhan, Cyong-Ru, Satange, Roshan, Wang, Shun-Ching, Zeng, Jing-Yi, Horng, Yih-Chern, Jin, Peng, Neidle, Stephen, Hou, Ming-Hon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450080/
https://www.ncbi.nlm.nih.gov/pubmed/33836081
http://dx.doi.org/10.1093/nar/gkab227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450080/
https://www.ncbi.nlm.nih.gov/pubmed/33836081
http://dx.doi.org/10.1093/nar/gkab227

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