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Cyclic mismatch binding ligands interact with disease-associated CGG trinucleotide repeats in RNA and suppress their translation

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder caused by a limited expansion of CGG repeats in the FMR1 gene. Degeneration of neurons in FXTAS cell models can be triggered by accumulation of polyglycine protein (FMRpolyG), a by-product of translation i...

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Detalles Bibliográficos
Autores principales: Konieczny, Patryk, Mukherjee, Sanjukta, Stepniak-Konieczna, Ewa, Taylor, Katarzyna, Niewiadomska, Daria, Piasecka, Agnieszka, Walczak, Agnieszka, Baud, Anna, Dohno, Chikara, Nakatani, Kazuhiko, Sobczak, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450082/
https://www.ncbi.nlm.nih.gov/pubmed/34358321
http://dx.doi.org/10.1093/nar/gkab669