Determining subpopulation methylation profiles from bisulfite sequencing data of heterogeneous samples using DXM

Epigenetic changes, such as aberrant DNA methylation, contribute to cancer clonal expansion and disease progression. However, identifying subpopulation-level changes in a heterogeneous sample remains challenging. Thus, we have developed a computational approach, DXM, to deconvolve the methylation pr...

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Detalles Bibliográficos
Autores principales: Fong, Jerry, Gardner, Jacob R, Andrews, Jared M, Cashen, Amanda F, Payton, Jacqueline E, Weinberger, Kilian Q, Edwards, John R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450090/
https://www.ncbi.nlm.nih.gov/pubmed/34157105
http://dx.doi.org/10.1093/nar/gkab516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450090/
https://www.ncbi.nlm.nih.gov/pubmed/34157105
http://dx.doi.org/10.1093/nar/gkab516

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