Genetic depletion of the RNA helicase DDX3 leads to impaired elongation of translating ribosomes triggering co-translational quality control of newly synthesized polypeptides

DDX3 is a multifaceted RNA helicase of the DEAD-box family that plays central roles in all aspects of RNA metabolism including translation initiation. Here, we provide evidence that the Leishmania DDX3 ortholog functions in post-initiation steps of translation. We show that genetic depletion of DDX3...

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Detalles Bibliográficos
Autores principales: Padmanabhan, Prasad Kottayil, Ferreira, Gabriel Reis, Zghidi-Abouzid, Ouafa, Oliveira, Camila, Dumas, Carole, Mariz, Filipe Colaço, Papadopoulou, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450092/
https://www.ncbi.nlm.nih.gov/pubmed/34358325
http://dx.doi.org/10.1093/nar/gkab667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450092/
https://www.ncbi.nlm.nih.gov/pubmed/34358325
http://dx.doi.org/10.1093/nar/gkab667

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