A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family

The SNM1 nucleases which help maintain genome integrity are members of the metallo-β-lactamase (MBL) structural superfamily. Their conserved MBL-β-CASP-fold SNM1 core provides a molecular scaffold forming an active site which coordinates the metal ions required for catalysis. The features that deter...

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Detalles Bibliográficos
Autores principales: Baddock, Hannah T, Newman, Joseph A, Yosaatmadja, Yuliana, Bielinski, Marcin, Schofield, Christopher J, Gileadi, Opher, McHugh, Peter J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450094/
https://www.ncbi.nlm.nih.gov/pubmed/34387694
http://dx.doi.org/10.1093/nar/gkab692

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450094/
https://www.ncbi.nlm.nih.gov/pubmed/34387694
http://dx.doi.org/10.1093/nar/gkab692

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