Handcuffing intrinsically disordered regions in Mlh1–Pms1 disrupts mismatch repair

The DNA mismatch repair (MMR) factor Mlh1–Pms1 contains long intrinsically disordered regions (IDRs) whose exact functions remain elusive. We performed cross-linking mass spectrometry to identify interactions within Mlh1–Pms1 and used this information to insert FRB and FKBP dimerization domains into...

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Detalles Bibliográficos
Autores principales: Furman, Christopher M, Wang, Ting-Yi, Zhao, Qiuye, Yugandhar, Kumar, Yu, Haiyuan, Alani, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450099/
https://www.ncbi.nlm.nih.gov/pubmed/34390347
http://dx.doi.org/10.1093/nar/gkab694

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450099/
https://www.ncbi.nlm.nih.gov/pubmed/34390347
http://dx.doi.org/10.1093/nar/gkab694

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