Cargando…

Handcuffing intrinsically disordered regions in Mlh1–Pms1 disrupts mismatch repair

The DNA mismatch repair (MMR) factor Mlh1–Pms1 contains long intrinsically disordered regions (IDRs) whose exact functions remain elusive. We performed cross-linking mass spectrometry to identify interactions within Mlh1–Pms1 and used this information to insert FRB and FKBP dimerization domains into...

Descripción completa

Detalles Bibliográficos
Autores principales:	Furman, Christopher M, Wang, Ting-Yi, Zhao, Qiuye, Yugandhar, Kumar, Yu, Haiyuan, Alani, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450099/ https://www.ncbi.nlm.nih.gov/pubmed/34390347 http://dx.doi.org/10.1093/nar/gkab694

Ejemplares similares

Intrinsically disordered regions regulate both catalytic and non-catalytic activities of the MutLα mismatch repair complex
por: Kim, Yoori, et al.
Publicado: (2019)

Rad9 plays an important role in DNA mismatch repair through physical interaction with MLH1
por: He, Wei, et al.
Publicado: (2008)

A conserved motif in the disordered linker of human MLH1 is vital for DNA mismatch repair and its function is diminished by a cancer family mutation
por: Wolf, Karla, et al.
Publicado: (2023)

GAA•TTC repeat expansion in human cells is mediated by mismatch repair complex MutLγ and depends upon the endonuclease domain in MLH3 isoform one
por: Halabi, Anasheh, et al.
Publicado: (2018)

Hydrolytic function of Exo1 in mammalian mismatch repair
por: Shao, Hongbing, et al.
Publicado: (2014)

Resolution of sequence divergence for repeat-mediated deletions shows a polarity that is mediated by MLH1
por: Trost, Hannah, et al.
Publicado: (2023)

Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex
por: Paul Solomon Devakumar, Lovely Jael, et al.
Publicado: (2019)

Human MLH1 suppresses the insertion of telomeric sequences at intra-chromosomal sites in telomerase-expressing cells
por: Jia, Pingping, et al.
Publicado: (2017)

An interplay of the base excision repair and mismatch repair pathways in active DNA demethylation
por: Grin, Inga, et al.
Publicado: (2016)

Mph1 requires mismatch repair-independent and -dependent functions of MutSα to regulate crossover formation during homologous recombination repair
por: Tay, Ye Dee, et al.
Publicado: (2010)

Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks
por: Zhao, Junhua, et al.
Publicado: (2009)

Epistatic role of base excision repair and mismatch repair pathways in mediating cisplatin cytotoxicity
por: Kothandapani, Anbarasi, et al.
Publicado: (2013)

SLX4 dampens MutSα-dependent mismatch repair
por: Guervilly, Jean-Hugues, et al.
Publicado: (2022)

Spatial coupling between DNA replication and mismatch repair in Caulobacter crescentus
por: Chai, Tiancong, et al.
Publicado: (2021)

Dual daughter strand incision is processive and increases the efficiency of DNA mismatch repair
por: Hermans, Nicolaas, et al.
Publicado: (2016)

Coordinated protein and DNA conformational changes govern mismatch repair initiation by MutS
por: LeBlanc, Sharonda J, et al.
Publicado: (2018)

DNA mismatch repair protects the genome from oxygen-induced replicative mutagenesis
por: Lózsa, Rita, et al.
Publicado: (2023)

MSH6- or PMS2-deficiency causes re-replication in DT40 B cells, but it has little effect on immunoglobulin gene conversion or on repair of AID-generated uracils
por: Campo, Vanina A., et al.
Publicado: (2013)

Mismatch-repair protein MSH6 is associated with Ku70 and regulates DNA double-strand break repair
por: Shahi, Ankita, et al.
Publicado: (2011)

The Kub5-Hera/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repair
por: Patidar, Praveen L., et al.
Publicado: (2016)

Stoichiometry of MutS and MutL at unrepaired mismatches in vivo suggests a mechanism of repair
por: Elez, Marina, et al.
Publicado: (2012)

Differences in genome-wide repeat sequence instability conferred by proofreading and mismatch repair defects
por: Lujan, Scott A., et al.
Publicado: (2015)

Disruption of PARP1 function inhibits base excision repair of a sub-set of DNA lesions
por: Reynolds, Pamela, et al.
Publicado: (2015)

Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation
por: Lv, Lingna, et al.
Publicado: (2013)

The ligation of pol β mismatch insertion products governs the formation of promutagenic base excision DNA repair intermediates
por: Çağlayan, Melike
Publicado: (2020)

Somatic CAG expansion in Huntington's disease is dependent on the MLH3 endonuclease domain, which can be excluded via splice redirection
por: Roy, Jennie C L, et al.
Publicado: (2021)

The mismatch repair endonuclease MutLα tethers duplex regions of DNA together and relieves DNA torsional tension
por: Witte, Scott J, et al.
Publicado: (2023)

The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair
por: Mardenborough, Yannicka S N, et al.
Publicado: (2019)

Aberrant repair initiated by mismatch-specific thymine-DNA glycosylases provides a mechanism for the mutational bias observed in CpG islands
por: Talhaoui, Ibtissam, et al.
Publicado: (2014)

Human DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro
por: Liu, Dekang, et al.
Publicado: (2017)

7,8-dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases
por: Talhaoui, Ibtissam, et al.
Publicado: (2013)

DNA mismatch repair and oligonucleotide end-protection promote base-pair substitution distal from a CRISPR/Cas9-induced DNA break
por: Harmsen, Tim, et al.
Publicado: (2018)

Enhanced spontaneous DNA twisting/bending fluctuations unveiled by fluorescence lifetime distributions promote mismatch recognition by the Rad4 nucleotide excision repair complex
por: Chakraborty, Sagnik, et al.
Publicado: (2018)

The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions
por: Orta, Manuel Luis, et al.
Publicado: (2014)

Differential modes of DNA binding by mismatch uracil DNA glycosylase from Escherichia coli: implications for abasic lesion processing and enzyme communication in the base excision repair pathway
por: Grippon, Seden, et al.
Publicado: (2011)

Mismatch repair and DNA polymerase δ proofreading prevent catastrophic accumulation of leading strand errors in cells expressing a cancer-associated DNA polymerase ϵ variant
por: Bulock, Chelsea R, et al.
Publicado: (2020)

Mechanism of formation of a toroid around DNA by the mismatch sensor protein
por: Nirwal, Shivlee, et al.
Publicado: (2018)

SIRT1 deacetylates APE1 and regulates cellular base excision repair
por: Yamamori, Tohru, et al.
Publicado: (2010)

Hug1 is an intrinsically disordered protein that inhibits ribonucleotide reductase activity by directly binding Rnr2 subunit
por: Meurisse, Julie, et al.
Publicado: (2014)

PARP1–TDP1 coupling for the repair of topoisomerase I–induced DNA damage
por: Das, Benu Brata, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_56oin72485f3ecaessbi13mmdb