Activation of bivalent factor DLX5 cooperates with master regulator TP63 to promote squamous cell carcinoma

To reconstruct systematically hyperactive transcription factor (TF)-dependent transcription networks in squamous cell carcinomas (SCCs), a computational method (ELMER) was applied to 1293 pan-SCC patient samples, and 44 hyperactive SCC TFs were identified. As a top candidate, DLX5 exhibits a notable...

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Detalles Bibliográficos
Autores principales: Huang, Yongsheng, Yang, Qian, Zheng, Yueyuan, Lin, Lehang, Xu, Xin, Xu, Xiu-E, Silva, Tiago C, Hazawa, Masaharu, Peng, Li, Cao, Haotian, Ding, Yanbing, Lu, Daning, Berman, Benjamin P, Xu, Li-Yan, Li, En-Min, Yin, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450110/
https://www.ncbi.nlm.nih.gov/pubmed/34370013
http://dx.doi.org/10.1093/nar/gkab679

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450110/
https://www.ncbi.nlm.nih.gov/pubmed/34370013
http://dx.doi.org/10.1093/nar/gkab679

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