LC–MS/MS Estimation of Rociletinib Levels in Human Liver Microsomes: Application to Metabolic Stability Estimation

BACKGROUND: Rociletinib (CO-1686; RLC) is a new, small molecule that is orally administered to inhibit mutant-selective covalent inhibitor of most epidermal growth factor receptor (EGFR)-mutated forms, including T790M, L858R, and exon 19 deletions, but not exon 20 insertions. Non–small-cell lung can...

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Detalles Bibliográficos
Autores principales: Attwa, Mohamed W, Abdelhameed, Ali S, Kadi, Adnan A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450377/
https://www.ncbi.nlm.nih.gov/pubmed/34552321
http://dx.doi.org/10.2147/DDDT.S321330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450377/
https://www.ncbi.nlm.nih.gov/pubmed/34552321
http://dx.doi.org/10.2147/DDDT.S321330

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