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Glypican 4 Regulates Aβ Internalization in Neural Stem Cells Partly via Low-Density Lipoprotein Receptor-Related Protein 1

Neural stem cell (NSC) damage has been reported in patients with Alzheimer’s disease. Intracellular Aβ plays a vital role in NSC damage. Heparan sulfate proteoglycans are potent mediators of Aβ enrichment in the brain. We hypothesized the heparan sulfate proteoglycan glypican 4 (Gpc4) regulates Aβ i...

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Detalles Bibliográficos
Autores principales: Ma, Kaige, Xing, Shan, Luan, Yan, Zhang, Chenglin, Liu, Yingfei, Fei, Yulang, Zhang, Zhichao, Liu, Yong, Chen, Xinlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450433/
https://www.ncbi.nlm.nih.gov/pubmed/34552470
http://dx.doi.org/10.3389/fncel.2021.732429