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Interactions and Cytotoxicity of Human Neurodegeneration- Associated Proteins Tau and α-Synuclein in the Simple Model Dictyostelium discoideum

The abnormal accumulation of the tau protein into aggregates is a hallmark in neurodegenerative diseases collectively known as tauopathies. In normal conditions, tau binds off and on microtubules aiding in their assembly and stability dependent on the phosphorylation state of the protein. In disease...

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Detalles Bibliográficos
Autores principales: Mroczek, Katelyn, Fernando, Sanjanie, Fisher, Paul R., Annesley, Sarah J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450459/
https://www.ncbi.nlm.nih.gov/pubmed/34552934
http://dx.doi.org/10.3389/fcell.2021.741662