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Effect of Missed Doses on the Therapeutic Effect of Methotrexate for Rheumatoid Arthritis: A Pharmacokinetic Modeling Study
INTRODUCTION: Patients rarely, if ever, take their medications exactly as prescribed. The extent to which missed doses interfere with a drug’s therapeutic effect remains unclear. METHODS: After weekly oral dosing of methotrexate (MTX) for rheumatoid arthritis, its polyglutamate derivatives (MTXglu)...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Dove
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450605/ https://www.ncbi.nlm.nih.gov/pubmed/34552357 http://dx.doi.org/10.2147/OARRR.S329178 |