A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA) linked to cell surface nucleolin depends on re-expression of the fetal polysialyltransferase ST8SIA2 gene

BACKGROUND: Polysialic acid (polySia) modifies six cell surface proteins in humans mainly during fetal development and some blood cells in adults. Two genes in humans, ST8SIA2 and ST8SIA4, code for polysialyltransferases that synthesize polySia. ST8SIA2 is highly expressed during fetal development a...

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Detalles Bibliográficos
Autores principales: Moe, Gregory R., Steirer, Lindsay M., Lee, Joshua A., Shivakumar, Adarsha, Bolanos, Alejandro D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451149/
https://www.ncbi.nlm.nih.gov/pubmed/34544457
http://dx.doi.org/10.1186/s13046-021-02099-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451149/
https://www.ncbi.nlm.nih.gov/pubmed/34544457
http://dx.doi.org/10.1186/s13046-021-02099-y

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