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A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA) linked to cell surface nucleolin depends on re-expression of the fetal polysialyltransferase ST8SIA2 gene
BACKGROUND: Polysialic acid (polySia) modifies six cell surface proteins in humans mainly during fetal development and some blood cells in adults. Two genes in humans, ST8SIA2 and ST8SIA4, code for polysialyltransferases that synthesize polySia. ST8SIA2 is highly expressed during fetal development a...
Autores principales: | Moe, Gregory R., Steirer, Lindsay M., Lee, Joshua A., Shivakumar, Adarsha, Bolanos, Alejandro D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451149/ https://www.ncbi.nlm.nih.gov/pubmed/34544457 http://dx.doi.org/10.1186/s13046-021-02099-y |
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