Differential effects of the novel neurosteroid hypnotic (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile on electroencephalogram activity in male and female rats

BACKGROUND: We recently showed that a neurosteroid analogue, (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile (3β-OH), induced hypnosis in rats. The aim of the present study was to evaluate the hypnotic and anaesthetic potential of 3β-OH further using electroencephalography. METHODS: We used behaviou...

Descripción completa

Detalles Bibliográficos
Autores principales: Joksimovic, Srdjan M., Sampath, Dayalan, Krishnan, Kathiresan, Covey, Douglas F., Jevtovic-Todorovic, Vesna, Raol, Yogendra H., Todorovic, Slobodan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Laboratory Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451239/
https://www.ncbi.nlm.nih.gov/pubmed/33972091
http://dx.doi.org/10.1016/j.bja.2021.03.029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451239/
https://www.ncbi.nlm.nih.gov/pubmed/33972091
http://dx.doi.org/10.1016/j.bja.2021.03.029

Ejemplares similares