Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s disease

The presenilin genes (PSEN1 and PSEN2) are mainly responsible for causing early-onset familial Alzheimer’s disease, harboring ~300 causative mutations, and representing ~90% of all mutations associated with a very aggressive disease form. Presenilin 1 is the catalytic core of the γ-secretase complex...

Descripción completa

Detalles Bibliográficos
Autores principales: Hernández-Sapiéns, Mercedes A., Reza-Zaldívar, Edwin E., Márquez-Aguirre, Ana L., Gómez-Pinedo, Ulises, Matias-Guiu, Jorge, Cevallos, Ricardo R., Mateos-Díaz, Juan C., Sánchez-González, Víctor J., Canales-Aguirre, Alejandro A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451546/
https://www.ncbi.nlm.nih.gov/pubmed/34100423
http://dx.doi.org/10.4103/1673-5374.313016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451546/
https://www.ncbi.nlm.nih.gov/pubmed/34100423
http://dx.doi.org/10.4103/1673-5374.313016

Ejemplares similares