Cargando…

Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s disease

The presenilin genes (PSEN1 and PSEN2) are mainly responsible for causing early-onset familial Alzheimer’s disease, harboring ~300 causative mutations, and representing ~90% of all mutations associated with a very aggressive disease form. Presenilin 1 is the catalytic core of the γ-secretase complex...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hernández-Sapiéns, Mercedes A., Reza-Zaldívar, Edwin E., Márquez-Aguirre, Ana L., Gómez-Pinedo, Ulises, Matias-Guiu, Jorge, Cevallos, Ricardo R., Mateos-Díaz, Juan C., Sánchez-González, Víctor J., Canales-Aguirre, Alejandro A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer - Medknow 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451546/ https://www.ncbi.nlm.nih.gov/pubmed/34100423 http://dx.doi.org/10.4103/1673-5374.313016

Ejemplares similares

Infection Mechanism of SARS-COV-2 and Its Implication on the Nervous System
por: Reza-Zaldívar, Edwin Estefan, et al.
Publicado: (2021)

A Three-Dimensional Alzheimer’s Disease Cell Culture Model Using iPSC-Derived Neurons Carrying A246E Mutation in PSEN1
por: Hernández-Sapiéns, Mercedes A., et al.
Publicado: (2020)

Dendritic Spine and Synaptic Plasticity in Alzheimer’s Disease: A Focus on MicroRNA
por: Reza-Zaldivar, Edwin Estefan, et al.
Publicado: (2020)

Exosomes and Biomaterials: In Search of a New Therapeutic Strategy for Multiple Sclerosis
por: Ojeda-Hernández, Doddy Denise, et al.
Publicado: (2022)

Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s disease
por: Reza-Zaldivar, Edwin E., et al.
Publicado: (2019)

Potential Effects of MSC-Derived Exosomes in Neuroplasticity in Alzheimer’s Disease
por: Reza-Zaldivar, Edwin E., et al.
Publicado: (2018)

Potential of Chitosan and Its Derivatives for Biomedical Applications in the Central Nervous System
por: Ojeda-Hernández, Doddy Denise, et al.
Publicado: (2020)

Chitosan–Hydroxycinnamic Acids Conjugates: Emerging Biomaterials with Rising Applications in Biomedicine
por: Ojeda-Hernández, Doddy Denise, et al.
Publicado: (2022)

Particles Containing Cells as a Strategy to Promote Remyelination in Patients With Multiple Sclerosis
por: Matías-Guiu, Jorge, et al.
Publicado: (2020)

Intranasal Administration of Undifferentiated Oligodendrocyte Lineage Cells as a Potential Approach to Deliver Oligodendrocyte Precursor Cells into Brain
por: Gómez-Pinedo, Ulises, et al.
Publicado: (2021)

Experimental Models for the Study of Central Nervous System Infection by SARS-CoV-2
por: Sanclemente-Alaman, Inmaculada, et al.
Publicado: (2020)

Notch Signalling in the Hippocampus of Patients With Motor Neuron Disease
por: Gómez-Pinedo, Ulises, et al.
Publicado: (2019)

Nose-to-Brain: The Next Step for Stem Cell and Biomaterial Therapy in Neurological Disorders
por: Villar-Gómez, Natalia, et al.
Publicado: (2022)

Immununochemical Markers of the Amyloid Cascade in the Hippocampus in Motor Neuron Diseases
por: Gómez-Pinedo, Ulises, et al.
Publicado: (2016)

Editorial: The Use of Biomaterials With Stem and Precursor Cells in Diseases of the Central Nervous System; A Step to Clinical Trials
por: Ramos-Zúñiga, Rodrigo, et al.
Publicado: (2021)

Genotoxic Effect of Chronic Exposure to DDT on Lymphocytes, Oral Mucosa and Breast Cells of Female Rats
por: Canales-Aguirre, Alejandro, et al.
Publicado: (2011)

Editorial: COVID-19 in CNS and PNS: Basic and Clinical Focus on the Mechanisms of Infection and New Tools for the Therapeutic Approach
por: Matias-Guiu, Jorge, et al.
Publicado: (2022)

Amyotrophic lateral sclerosis modifies progenitor neural proliferation in adult classic neurogenic brain niches
por: Galán, Lucía, et al.
Publicado: (2017)

Presenilins in Alzheimer’s disease and frontotemporal dementia
por: Shen, Jie
Publicado: (2012)

Function and dysfunction of presenilin in Alzheimer’s disease
por: Shen, Jie
Publicado: (2013)

Variants of genes encoding TNF receptors and ligands and proteins regulating TNF activation in familial multiple sclerosis
por: Torre‐Fuentes, Laura, et al.
Publicado: (2020)

Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer’s Disease-Associated Presenilin 1 Mutation
por: Martín-Maestro, Patricia, et al.
Publicado: (2017)

Exonic variants of genes related to the vitamin D signaling pathway in the families of familial multiple sclerosis using whole‐exome next generation sequencing
por: Pytel, Vanesa, et al.
Publicado: (2019)

Alexander Disease Mutations Produce Cells with Coexpression of Glial Fibrillary Acidic Protein and NG2 in Neurosphere Cultures and Inhibit Differentiation into Mature Oligodendrocytes
por: Gómez-Pinedo, Ulises, et al.
Publicado: (2017)

Modeling Presenilin-Dependent Familial Alzheimer's Disease: Emphasis on Presenilin Substrate-Mediated Signaling and Synaptic Function
por: Parent, Angèle T., et al.
Publicado: (2010)

The presenilins
por: Tandon, Anurag, et al.
Publicado: (2002)

CSF Presenilin-1 complexes are increased in Alzheimer’s disease
por: García-Ayllón, María-Salud, et al.
Publicado: (2013)

Inhibition of the Neuronal Calcium Sensor DREAM Modulates Presenilin-2 Endoproteolysis
por: Naranjo, Rocío, et al.
Publicado: (2018)

Mental Disorders in Young Adults from Families with the Presenilin-1 Gene Mutation E280A in the Preclinical Stage of Alzheimer’s Disease
por: Villalba, Arvey Camilo, et al.
Publicado: (2019)

Human-Induced Neurons from Presenilin 1 Mutant Patients Model Aspects of Alzheimer’s Disease Pathology
por: Schrank, Sean, et al.
Publicado: (2020)

Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease
por: Honarnejad, Kamran, et al.
Publicado: (2013)

Familial multiple sclerosis and association with other autoimmune diseases
por: Pytel, Vanesa, et al.
Publicado: (2017)

Vitamin D increases remyelination by promoting oligodendrocyte lineage differentiation
por: Gomez‐Pinedo, Ulises, et al.
Publicado: (2019)

Discovery of novel benzophenone integrated derivatives as anti-Alzheimer’s agents targeting presenilin-1 and presenilin-2 inhibition: A computational approach
por: Martiz, Reshma Mary, et al.
Publicado: (2022)

Presenilin-Deficient Neurons and Astrocytes Display Normal Mitochondrial Phenotypes
por: Contino, Sabrina, et al.
Publicado: (2021)

Protein Predictive Modeling and Simulation of Mutations of Presenilin-1 Familial Alzheimer’s Disease on the Orthosteric Site
por: Soto-Ospina, Alejandro, et al.
Publicado: (2021)

Adult hippocampal neurogenesis occurs in the absence of Presenilin 1 and Presenilin 2
por: Dhaliwal, Jagroop, et al.
Publicado: (2018)

Structure and dynamics of γ-secretase with presenilin 2 compared to presenilin 1
por: Dehury, Budheswar, et al.
Publicado: (2019)

The Role of Presenilin and its Interacting Proteins in the Biogenesis of Alzheimer’s Beta Amyloid
por: Verdile, Giuseppe, et al.
Publicado: (2006)

Alternative splicing in a presenilin 2 variant associated with Alzheimer disease
por: Braggin, Jacquelyn E., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_btifs3ra83otu221ejosp0j887