Safety, Pharmacokinetics, and Pharmacodynamics of Trazpiroben (TAK‐906), a Novel Selective D(2)/D(3) Receptor Antagonist: A Phase 1 Randomized, Placebo‐Controlled Single‐ and Multiple‐Dose Escalation Study in Healthy Participants

Gastroparesis is a chronic neuromuscular disorder of the upper gastrointestinal tract in which episodic exacerbation can lead to frequent hospitalizations and severe disability. Dopamine D(2)/D(3) receptor antagonists have been used to treat patients with gastroparesis with some efficacy; however, t...

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Detalles Bibliográficos
Autores principales: Whiting, Roger L., Darpo, Borje, Chen, Chunlin, Fletcher, Margaret, Combs, Dan, Xue, Hongqi, Stoltz, Randall R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451790/
https://www.ncbi.nlm.nih.gov/pubmed/33462988
http://dx.doi.org/10.1002/cpdd.906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451790/
https://www.ncbi.nlm.nih.gov/pubmed/33462988
http://dx.doi.org/10.1002/cpdd.906

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