A Phase 1 Study of KHK4083: A Single‐Blind, Randomized, Placebo‐Controlled Single‐Ascending‐Dose Study in Healthy Adults and an Open‐Label Multiple‐Dose Study in Patients With Ulcerative Colitis

OX40 plays an essential role in maintaining late T‐cell proliferation and survival by suppressing apoptosis and by inducing T‐cell memory formation. Here, we report the results of the phase 1 study of KHK4083, a fully human antimonoclonal antibody specific for OX40. In this study, we aimed to assess...

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Detalles Bibliográficos
Autores principales: Furihata, Kenichi, Ishiguro, Yoh, Yoshimura, Naoki, Ito, Hiroaki, Katsushima, Shinji, Kaneko, Etsuji, Shimabe, Munetake, Mukai, Mayumi, Watanabe, Risa, Morishige, Takuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451804/
https://www.ncbi.nlm.nih.gov/pubmed/33512065
http://dx.doi.org/10.1002/cpdd.918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451804/
https://www.ncbi.nlm.nih.gov/pubmed/33512065
http://dx.doi.org/10.1002/cpdd.918

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