Population pharmacokinetic analysis of RO5459072, a low water‐soluble drug exhibiting complex food–drug interactions

AIMS: RO5459072, a cathepsin‐S inhibitor, Biopharmaceutics Classification System class 2 and P‐glycoprotein substrate, exhibited complex, nonlinear pharmacokinetics (PK) while fasted that seemed to impact both the absorption and the disposition phases. When given with food, all nonlinearities disapp...

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Detalles Bibliográficos
Autores principales: Kratochwil, Nicole A., Stillhart, Cordula, Diack, Cheikh, Nagel, Sandra, Al Kotbi, Nada, Frey, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451882/
https://www.ncbi.nlm.nih.gov/pubmed/33576513
http://dx.doi.org/10.1111/bcp.14771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451882/
https://www.ncbi.nlm.nih.gov/pubmed/33576513
http://dx.doi.org/10.1111/bcp.14771

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