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Population pharmacokinetic analysis of RO5459072, a low water‐soluble drug exhibiting complex food–drug interactions
AIMS: RO5459072, a cathepsin‐S inhibitor, Biopharmaceutics Classification System class 2 and P‐glycoprotein substrate, exhibited complex, nonlinear pharmacokinetics (PK) while fasted that seemed to impact both the absorption and the disposition phases. When given with food, all nonlinearities disapp...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451882/ https://www.ncbi.nlm.nih.gov/pubmed/33576513 http://dx.doi.org/10.1111/bcp.14771 |