Generation of iPSC line from a Parkinson patient with PARK7 mutation and CRISPR-edited Gibco human episomal iPSC line to mimic PARK7 mutation

Mutations in the oncogene PARK7, which codes for DJ-1, have been associated with early-onset autosomal recessive Parkinson’s disease (PD); however, the exact role of DJ-1 in PD remains elusive. Fibroblasts from a PD patient with a uniparental disomy, 1 bp deletion in PARK7 were reprogrammed into the...

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Detalles Bibliográficos
Autores principales: Mazza, Melissa Conti, Beilina, Alexandra, Roosen, Dorien A., Hauser, David, Cookson, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451958/
https://www.ncbi.nlm.nih.gov/pubmed/34419745
http://dx.doi.org/10.1016/j.scr.2021.102506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451958/
https://www.ncbi.nlm.nih.gov/pubmed/34419745
http://dx.doi.org/10.1016/j.scr.2021.102506

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