Estimating fetal exposure to the P‐gp substrates, corticosteroids, by PBPK modeling to inform prevention of neonatal respiratory distress syndrome

We have previously developed a maternal‐fetal physiologically‐based pharmacokinetic (m‐f PBPK) model to dynamically predict (and verify) fetal‐maternal exposure to drugs that passively diffuse across the placenta. Here, we extended the application of this model to dynamically predict fetal exposure...

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Detalles Bibliográficos
Autores principales: Anoshchenko, Olena, Milad, Mark A., Unadkat, Jashvant D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452292/
https://www.ncbi.nlm.nih.gov/pubmed/34273255
http://dx.doi.org/10.1002/psp4.12674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452292/
https://www.ncbi.nlm.nih.gov/pubmed/34273255
http://dx.doi.org/10.1002/psp4.12674

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