Synaptotagmin 7 is targeted to the axonal plasma membrane through γ-secretase processing to promote synaptic vesicle docking in mouse hippocampal neurons

Synaptotagmin 7 (SYT7) has emerged as a key regulator of presynaptic function, but its localization and precise role in the synaptic vesicle cycle remain the subject of debate. Here, we used iGluSnFR to optically interrogate glutamate release, at the single-bouton level, in SYT7KO-dissociated mouse...

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Detalles Bibliográficos
Autores principales: Vevea, Jason D, Kusick, Grant F, Courtney, Kevin C, Chen, Erin, Watanabe, Shigeki, Chapman, Edwin R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452306/
https://www.ncbi.nlm.nih.gov/pubmed/34543184
http://dx.doi.org/10.7554/eLife.67261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452306/
https://www.ncbi.nlm.nih.gov/pubmed/34543184
http://dx.doi.org/10.7554/eLife.67261

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