Progesterone receptor-DNA methylation crosstalk regulates depletion of uterine leiomyoma stem cells: A potential therapeutic target

Uterine leiomyoma (LM) is the most common tumor in women. Via its receptor (PGR) expressed in differentiated LM cells, progesterone stimulates paracrine signaling that induces proliferation of PGR-deficient LM stem cells (LSCs). Antiprogestins shrink LM but tumors regrow after treatment cessation po...

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Detalles Bibliográficos
Autores principales: Liu, Shimeng, Yin, Ping, Xu, Jingting, Dotts, Ariel J., Kujawa, Stacy A., Coon V, John S., Zhao, Hong, Dai, Yang, Bulun, Serdar E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452515/
https://www.ncbi.nlm.nih.gov/pubmed/34388365
http://dx.doi.org/10.1016/j.stemcr.2021.07.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452515/
https://www.ncbi.nlm.nih.gov/pubmed/34388365
http://dx.doi.org/10.1016/j.stemcr.2021.07.013

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