NOTCH-mediated ex vivo expansion of human hematopoietic stem and progenitor cells by culture under hypoxia

Activation of NOTCH signaling in human hematopoietic stem/progenitor cells (HSPCs) by treatment with an engineered Delta-like ligand (DELTA1(ext-IgG) [DXI]) has enabled ex vivo expansion of short-term HSPCs, but the effect on long-term repopulating hematopoietic stem cells (LTR-HSCs) remains uncerta...

Descripción completa

Detalles Bibliográficos
Autores principales: Araki, Daisuke, Fu, Jian Fei, Huntsman, Heather, Cordes, Stefan, Seifuddin, Fayaz, Alvarado, Luigi J., Cheruku, Patali S., Cash, Ayla, Traba, Javier, Li, Yuesheng, Pirooznia, Mehdi, Smith, Richard H., Larochelle, Andre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452537/
https://www.ncbi.nlm.nih.gov/pubmed/34450041
http://dx.doi.org/10.1016/j.stemcr.2021.08.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452537/
https://www.ncbi.nlm.nih.gov/pubmed/34450041
http://dx.doi.org/10.1016/j.stemcr.2021.08.001

Ejemplares similares