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NOTCH-mediated ex vivo expansion of human hematopoietic stem and progenitor cells by culture under hypoxia

Activation of NOTCH signaling in human hematopoietic stem/progenitor cells (HSPCs) by treatment with an engineered Delta-like ligand (DELTA1(ext-IgG) [DXI]) has enabled ex vivo expansion of short-term HSPCs, but the effect on long-term repopulating hematopoietic stem cells (LTR-HSCs) remains uncerta...

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Detalles Bibliográficos
Autores principales:	Araki, Daisuke, Fu, Jian Fei, Huntsman, Heather, Cordes, Stefan, Seifuddin, Fayaz, Alvarado, Luigi J., Cheruku, Patali S., Cash, Ayla, Traba, Javier, Li, Yuesheng, Pirooznia, Mehdi, Smith, Richard H., Larochelle, Andre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452537/ https://www.ncbi.nlm.nih.gov/pubmed/34450041 http://dx.doi.org/10.1016/j.stemcr.2021.08.001

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