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Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition
Neuromuscular junctions (NMJs) ensure communication between motor neurons (MNs) and muscle; however, in MN disorders, such as amyotrophic lateral sclerosis (ALS), NMJs degenerate resulting in muscle atrophy. The aim of this study was to establish a versatile and reproducible in vitro model of a huma...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452598/ https://www.ncbi.nlm.nih.gov/pubmed/33891869 http://dx.doi.org/10.1016/j.stemcr.2021.03.029 |