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Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition
Neuromuscular junctions (NMJs) ensure communication between motor neurons (MNs) and muscle; however, in MN disorders, such as amyotrophic lateral sclerosis (ALS), NMJs degenerate resulting in muscle atrophy. The aim of this study was to establish a versatile and reproducible in vitro model of a huma...
Autores principales: | Stoklund Dittlau, Katarina, Krasnow, Emily N., Fumagalli, Laura, Vandoorne, Tijs, Baatsen, Pieter, Kerstens, Axelle, Giacomazzi, Giorgia, Pavie, Benjamin, Rossaert, Elisabeth, Beckers, Jimmy, Sampaolesi, Maurilio, Van Damme, Philip, Van Den Bosch, Ludo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452598/ https://www.ncbi.nlm.nih.gov/pubmed/33891869 http://dx.doi.org/10.1016/j.stemcr.2021.03.029 |
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