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Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition

Neuromuscular junctions (NMJs) ensure communication between motor neurons (MNs) and muscle; however, in MN disorders, such as amyotrophic lateral sclerosis (ALS), NMJs degenerate resulting in muscle atrophy. The aim of this study was to establish a versatile and reproducible in vitro model of a huma...

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Detalles Bibliográficos
Autores principales:	Stoklund Dittlau, Katarina, Krasnow, Emily N., Fumagalli, Laura, Vandoorne, Tijs, Baatsen, Pieter, Kerstens, Axelle, Giacomazzi, Giorgia, Pavie, Benjamin, Rossaert, Elisabeth, Beckers, Jimmy, Sampaolesi, Maurilio, Van Damme, Philip, Van Den Bosch, Ludo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452598/ https://www.ncbi.nlm.nih.gov/pubmed/33891869 http://dx.doi.org/10.1016/j.stemcr.2021.03.029

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