Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1

Doublecortin-like kinase 1 (DCLK1) is an understudied bi-functional kinase with a proven role in tumour growth and development. However, the presence of tissue-specific spliced DCLK1 isoforms with distinct biological functions have challenged the development of effective strategies to understand the...

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Detalles Bibliográficos
Autores principales: Patel, Onisha, Roy, Michael J., Kropp, Ashleigh, Hardy, Joshua M., Dai, Weiwen, Lucet, Isabelle S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452690/
https://www.ncbi.nlm.nih.gov/pubmed/34545159
http://dx.doi.org/10.1038/s42003-021-02631-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452690/
https://www.ncbi.nlm.nih.gov/pubmed/34545159
http://dx.doi.org/10.1038/s42003-021-02631-y

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