Cargando…
Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1
Doublecortin-like kinase 1 (DCLK1) is an understudied bi-functional kinase with a proven role in tumour growth and development. However, the presence of tissue-specific spliced DCLK1 isoforms with distinct biological functions have challenged the development of effective strategies to understand the...
Autores principales: | Patel, Onisha, Roy, Michael J., Kropp, Ashleigh, Hardy, Joshua M., Dai, Weiwen, Lucet, Isabelle S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452690/ https://www.ncbi.nlm.nih.gov/pubmed/34545159 http://dx.doi.org/10.1038/s42003-021-02631-y |
Ejemplares similares
-
Targeting Doublecortin-Like Kinase 1 (DCLK1)-Regulated SARS-CoV-2 Pathogenesis in COVID-19
por: Undi, Ram Babu, et al.
Publicado: (2022) -
Doublecortin-Like Kinase 1 (DCLK1) Is a Novel NOTCH Pathway Signaling Regulator in Head and Neck Squamous Cell Carcinoma
por: Broner, Esther C., et al.
Publicado: (2021) -
Structure-Guided Prediction of the Functional Impact of DCLK1 Mutations on Tumorigenesis
por: Carli, Annalisa L. E., et al.
Publicado: (2023) -
Inflammatory and oncogenic roles of a tumor stem cell marker doublecortin-like kinase (DCLK1) in virus-induced chronic liver diseases
por: Ali, Naushad, et al.
Publicado: (2015) -
Structural Basis of Inhibition of DCLK1 by Ruxolitinib
por: Jang, Dong Man, et al.
Publicado: (2021)