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HIV reprograms host m(6)Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1
N(6),2′-O-dimethyladenosine (m(6)Am) is an abundant RNA modification located adjacent to the 5′-end of the mRNA 7-methylguanosine (m(7)G) cap structure. m(6)A methylation on 2′-O-methylated A at the 5′-ends of mRNAs is catalyzed by the methyltransferase Phosphorylated CTD Interacting Factor 1 (PCIF1...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452764/ https://www.ncbi.nlm.nih.gov/pubmed/34545078 http://dx.doi.org/10.1038/s41467-021-25683-4 |