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PAQR9 regulates hepatic ketogenesis and fatty acid oxidation during fasting by modulating protein stability of PPARα

BACKGROUND: The cycle of feeding and fasting is fundamental to life and closely coordinated with changes of metabolic programs. During extended starvation, ketogenesis coupled with fatty acid oxidation in the liver supplies ketone bodies to extrahepatic tissues as the major form of fuel. In this stu...

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Detalles Bibliográficos
Autores principales: Lin, Yijun, Chen, Lingling, You, Xue, Li, Zixuan, Li, Chenchen, Chen, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452888/
https://www.ncbi.nlm.nih.gov/pubmed/34474167
http://dx.doi.org/10.1016/j.molmet.2021.101331