Rigidifying a De Novo Enzyme Increases Activity and Induces a Negative Activation Heat Capacity

[Image: see text] Conformational sampling profoundly impacts the overall activity and temperature dependence of enzymes. Peroxidases have emerged as versatile platforms for high-value biocatalysis owing to their broad palette of potential biotransformations. Here, we explore the role of conformation...

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Detalles Bibliográficos
Autores principales: Hindson, Sarah A., Bunzel, H. Adrian, Frank, Bettina, Svistunenko, Dimitri A., Williams, Christopher, van der Kamp, Marc W., Mulholland, Adrian J., Pudney, Christopher R., Anderson, J. L. Ross
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453482/
https://www.ncbi.nlm.nih.gov/pubmed/34557328
http://dx.doi.org/10.1021/acscatal.1c01776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453482/
https://www.ncbi.nlm.nih.gov/pubmed/34557328
http://dx.doi.org/10.1021/acscatal.1c01776

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