Napabucasin Drug‐Drug Interaction Potential, Safety, Tolerability, and Pharmacokinetics Following Oral Dosing in Healthy Adult Volunteers

Napabucasin is an orally administered reactive oxygen species generator that is bioactivated by the intracellular antioxidant nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase 1. Napabucasin induces cell death in cancer cells, including cancer stem cells. This phase 1 study (NCT0341...

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Detalles Bibliográficos
Autores principales: Dai, Xiaoshu, Karol, Michael D., Hitron, Matthew, Hard, Marjie L., Goulet, Matthew T., McLaughlin, Colleen F., Brantley, Scott J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453567/
https://www.ncbi.nlm.nih.gov/pubmed/34107166
http://dx.doi.org/10.1002/cpdd.961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453567/
https://www.ncbi.nlm.nih.gov/pubmed/34107166
http://dx.doi.org/10.1002/cpdd.961

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