In‐Cell Characterization of the Stable Tyrosyl Radical in E. coli Ribonucleotide Reductase Using Advanced EPR Spectroscopy

The E. coli ribonucleotide reductase (RNR), a paradigm for class Ia enzymes including human RNR, catalyzes the biosynthesis of DNA building blocks and requires a di‐iron tyrosyl radical (Y(122) (.)) cofactor for activity. The knowledge on the in vitro Y(122) (.) structure and its radical distributio...

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Detalles Bibliográficos
Autores principales: Meichsner, Shari L., Kutin, Yury, Kasanmascheff, Müge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453577/
https://www.ncbi.nlm.nih.gov/pubmed/33844392
http://dx.doi.org/10.1002/anie.202102914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453577/
https://www.ncbi.nlm.nih.gov/pubmed/33844392
http://dx.doi.org/10.1002/anie.202102914

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