Piperidine Azasugars Bearing Lipophilic Chains: Stereoselective Synthesis and Biological Activity as Inhibitors of Glucocerebrosidase (GCase)

[Image: see text] We report a straightforward synthetic strategy for the preparation of trihydroxypiperidine azasugars decorated with lipophilic chains at both the nitrogen and the adjacent carbon as potential inhibitors of the lysosomal enzyme glucocerebrosidase (GCase), which is involved in Gauche...

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Detalles Bibliográficos
Autores principales: Clemente, Francesca, Matassini, Camilla, Giachetti, Sara, Goti, Andrea, Morrone, Amelia, Martínez-Bailén, Macarena, Orta, Sara, Merino, Pedro, Cardona, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453635/
https://www.ncbi.nlm.nih.gov/pubmed/34469155
http://dx.doi.org/10.1021/acs.joc.1c01308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453635/
https://www.ncbi.nlm.nih.gov/pubmed/34469155
http://dx.doi.org/10.1021/acs.joc.1c01308

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