Meta‐Analysis of Noncompartmental Pharmacokinetic Parameters of Ertugliflozin to Evaluate Dose Proportionality and UGT1A9 Polymorphism Effect on Exposure

Ertugliflozin, a sodium‐glucose cotransporter 2 inhibitor, is primarily metabolized via glucuronidation by the uridine 5′‐diphospho‐glucuronosyltransferase (UGT) isoform UGT1A9. This noncompartmental meta‐analysis of ertugliflozin pharmacokinetics evaluated the relationship between ertugliflozin exp...

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Detalles Bibliográficos
Autores principales: Marshall, Jean‐Claude, Liang, Yali, Sahasrabudhe, Vaishali, Tensfeldt, Thomas, Fediuk, Daryl J., Zhou, Susan, Krishna, Rajesh, Dawra, Vikas Kumar, Wood, Linda S., Sweeney, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Pharmacogenomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453771/
https://www.ncbi.nlm.nih.gov/pubmed/33813736
http://dx.doi.org/10.1002/jcph.1866

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453771/
https://www.ncbi.nlm.nih.gov/pubmed/33813736
http://dx.doi.org/10.1002/jcph.1866

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