Bleeding complications in patients with squamous cell carcinoma of the head and neck

Hemorrhage in recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) may be attributed to chemotherapy and local tumor irradiation. Evidence of the relationship between hemorrhage in R/M HNSCC and targeted therapies, including epidermal growth factor receptor (EGFR) and vasc...

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Autores principales: Bergamini, Cristiana, Ferris, Robert L., Xie, Jing, Mariani, Gabriella, Ali, Muzammil, Holmes, William C., Harrington, Kevin, Psyrri, Amanda, Cavalieri, Stefano, Licitra, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453784/
https://www.ncbi.nlm.nih.gov/pubmed/34117666
http://dx.doi.org/10.1002/hed.26772
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author Bergamini, Cristiana
Ferris, Robert L.
Xie, Jing
Mariani, Gabriella
Ali, Muzammil
Holmes, William C.
Harrington, Kevin
Psyrri, Amanda
Cavalieri, Stefano
Licitra, Lisa
author_facet Bergamini, Cristiana
Ferris, Robert L.
Xie, Jing
Mariani, Gabriella
Ali, Muzammil
Holmes, William C.
Harrington, Kevin
Psyrri, Amanda
Cavalieri, Stefano
Licitra, Lisa
author_sort Bergamini, Cristiana
collection PubMed
description Hemorrhage in recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) may be attributed to chemotherapy and local tumor irradiation. Evidence of the relationship between hemorrhage in R/M HNSCC and targeted therapies, including epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) inhibitors, or immune checkpoint inhibitors, is limited. We aimed to identify epidemiological and clinical data related to the occurrence of hemorrhage in R/M HNSCC and to explore its relationship with various therapies. We describe information obtained from literature searches as well as data extracted from a commercial database and a database from the author's institution (Istituto Nazionale dei Tumori of Milan). Evidence suggests that most bleeding events in R/M HNSCC are minor. Clinical trial safety data do not identify a causal association between hemorrhage and anti‐EGFR agents or immune checkpoint inhibitors. In contrast, anti‐VEGF agents are associated with increased, and often severe/fatal, hemorrhagic complications.
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spelling pubmed-84537842021-09-27 Bleeding complications in patients with squamous cell carcinoma of the head and neck Bergamini, Cristiana Ferris, Robert L. Xie, Jing Mariani, Gabriella Ali, Muzammil Holmes, William C. Harrington, Kevin Psyrri, Amanda Cavalieri, Stefano Licitra, Lisa Head Neck Clinical Reviews Hemorrhage in recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) may be attributed to chemotherapy and local tumor irradiation. Evidence of the relationship between hemorrhage in R/M HNSCC and targeted therapies, including epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) inhibitors, or immune checkpoint inhibitors, is limited. We aimed to identify epidemiological and clinical data related to the occurrence of hemorrhage in R/M HNSCC and to explore its relationship with various therapies. We describe information obtained from literature searches as well as data extracted from a commercial database and a database from the author's institution (Istituto Nazionale dei Tumori of Milan). Evidence suggests that most bleeding events in R/M HNSCC are minor. Clinical trial safety data do not identify a causal association between hemorrhage and anti‐EGFR agents or immune checkpoint inhibitors. In contrast, anti‐VEGF agents are associated with increased, and often severe/fatal, hemorrhagic complications. John Wiley & Sons, Inc. 2021-06-12 2021-09 /pmc/articles/PMC8453784/ /pubmed/34117666 http://dx.doi.org/10.1002/hed.26772 Text en © 2021 The Authors. Head & Neck published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Clinical Reviews
Bergamini, Cristiana
Ferris, Robert L.
Xie, Jing
Mariani, Gabriella
Ali, Muzammil
Holmes, William C.
Harrington, Kevin
Psyrri, Amanda
Cavalieri, Stefano
Licitra, Lisa
Bleeding complications in patients with squamous cell carcinoma of the head and neck
title Bleeding complications in patients with squamous cell carcinoma of the head and neck
title_full Bleeding complications in patients with squamous cell carcinoma of the head and neck
title_fullStr Bleeding complications in patients with squamous cell carcinoma of the head and neck
title_full_unstemmed Bleeding complications in patients with squamous cell carcinoma of the head and neck
title_short Bleeding complications in patients with squamous cell carcinoma of the head and neck
title_sort bleeding complications in patients with squamous cell carcinoma of the head and neck
topic Clinical Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453784/
https://www.ncbi.nlm.nih.gov/pubmed/34117666
http://dx.doi.org/10.1002/hed.26772
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