Bleeding complications in patients with squamous cell carcinoma of the head and neck
Hemorrhage in recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) may be attributed to chemotherapy and local tumor irradiation. Evidence of the relationship between hemorrhage in R/M HNSCC and targeted therapies, including epidermal growth factor receptor (EGFR) and vasc...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453784/ https://www.ncbi.nlm.nih.gov/pubmed/34117666 http://dx.doi.org/10.1002/hed.26772 |
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author | Bergamini, Cristiana Ferris, Robert L. Xie, Jing Mariani, Gabriella Ali, Muzammil Holmes, William C. Harrington, Kevin Psyrri, Amanda Cavalieri, Stefano Licitra, Lisa |
author_facet | Bergamini, Cristiana Ferris, Robert L. Xie, Jing Mariani, Gabriella Ali, Muzammil Holmes, William C. Harrington, Kevin Psyrri, Amanda Cavalieri, Stefano Licitra, Lisa |
author_sort | Bergamini, Cristiana |
collection | PubMed |
description | Hemorrhage in recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) may be attributed to chemotherapy and local tumor irradiation. Evidence of the relationship between hemorrhage in R/M HNSCC and targeted therapies, including epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) inhibitors, or immune checkpoint inhibitors, is limited. We aimed to identify epidemiological and clinical data related to the occurrence of hemorrhage in R/M HNSCC and to explore its relationship with various therapies. We describe information obtained from literature searches as well as data extracted from a commercial database and a database from the author's institution (Istituto Nazionale dei Tumori of Milan). Evidence suggests that most bleeding events in R/M HNSCC are minor. Clinical trial safety data do not identify a causal association between hemorrhage and anti‐EGFR agents or immune checkpoint inhibitors. In contrast, anti‐VEGF agents are associated with increased, and often severe/fatal, hemorrhagic complications. |
format | Online Article Text |
id | pubmed-8453784 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84537842021-09-27 Bleeding complications in patients with squamous cell carcinoma of the head and neck Bergamini, Cristiana Ferris, Robert L. Xie, Jing Mariani, Gabriella Ali, Muzammil Holmes, William C. Harrington, Kevin Psyrri, Amanda Cavalieri, Stefano Licitra, Lisa Head Neck Clinical Reviews Hemorrhage in recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) may be attributed to chemotherapy and local tumor irradiation. Evidence of the relationship between hemorrhage in R/M HNSCC and targeted therapies, including epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) inhibitors, or immune checkpoint inhibitors, is limited. We aimed to identify epidemiological and clinical data related to the occurrence of hemorrhage in R/M HNSCC and to explore its relationship with various therapies. We describe information obtained from literature searches as well as data extracted from a commercial database and a database from the author's institution (Istituto Nazionale dei Tumori of Milan). Evidence suggests that most bleeding events in R/M HNSCC are minor. Clinical trial safety data do not identify a causal association between hemorrhage and anti‐EGFR agents or immune checkpoint inhibitors. In contrast, anti‐VEGF agents are associated with increased, and often severe/fatal, hemorrhagic complications. John Wiley & Sons, Inc. 2021-06-12 2021-09 /pmc/articles/PMC8453784/ /pubmed/34117666 http://dx.doi.org/10.1002/hed.26772 Text en © 2021 The Authors. Head & Neck published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Clinical Reviews Bergamini, Cristiana Ferris, Robert L. Xie, Jing Mariani, Gabriella Ali, Muzammil Holmes, William C. Harrington, Kevin Psyrri, Amanda Cavalieri, Stefano Licitra, Lisa Bleeding complications in patients with squamous cell carcinoma of the head and neck |
title | Bleeding complications in patients with squamous cell carcinoma of the head and neck |
title_full | Bleeding complications in patients with squamous cell carcinoma of the head and neck |
title_fullStr | Bleeding complications in patients with squamous cell carcinoma of the head and neck |
title_full_unstemmed | Bleeding complications in patients with squamous cell carcinoma of the head and neck |
title_short | Bleeding complications in patients with squamous cell carcinoma of the head and neck |
title_sort | bleeding complications in patients with squamous cell carcinoma of the head and neck |
topic | Clinical Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453784/ https://www.ncbi.nlm.nih.gov/pubmed/34117666 http://dx.doi.org/10.1002/hed.26772 |
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