Generation of Stable Isopentenyl Monophosphate Aryloxy Triester Phosphoramidates as Activators of Vγ9Vδ2 T Cells

Aryloxy triester phosphoramidate prodrugs of the monophosphate derivatives of isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP) were synthesized as lipophilic derivatives that can improve cell uptake. Despite the structural similarity of IPP and DMAPP, it was noted that their p...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Qin, Taher, Taher E., Ashby, Elizabeth, Sharif, Maria, Willcox, Benjamin E., Mehellou, Youcef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453817/
https://www.ncbi.nlm.nih.gov/pubmed/33899332
http://dx.doi.org/10.1002/cmdc.202100198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453817/
https://www.ncbi.nlm.nih.gov/pubmed/33899332
http://dx.doi.org/10.1002/cmdc.202100198

Ejemplares similares