Development and in vitro Profiling of Dual FXR/LTA4H Modulators

Designed polypharmacology presents as an attractive strategy to increase therapeutic efficacy in multi‐factorial diseases by a directed modulation of multiple involved targets with a single molecule. Such an approach appears particularly suitable in non‐alcoholic steatohepatitis (NASH) which involve...

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Detalles Bibliográficos
Autores principales: Schierle, Simone, Brunst, Steffen, Helmstädter, Moritz, Ebert, Roland, Kramer, Jan S., Steinhilber, Dieter, Proschak, Ewgenij, Merk, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453936/
https://www.ncbi.nlm.nih.gov/pubmed/33856122
http://dx.doi.org/10.1002/cmdc.202100118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453936/
https://www.ncbi.nlm.nih.gov/pubmed/33856122
http://dx.doi.org/10.1002/cmdc.202100118

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